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Evidence found and GRADE certainty

3 questions · 7 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 85.7%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Methotrexate vs 6‐MP or azathioprine

Withdrawals due to adverse events · adult patients with refractory Crohn's disease

It is very uncertain whether methotrexate changes withdrawal due to adverse event (Oren 1997) compared with 6‐MP or azathioprine (very low certainty).

3 findings from 1 review

Methotrexate vs 6‐MP or azathioprine

Failure to enter remission or possible remission at 16 weeks (Arora 1999) · adult patients with refractory Crohn's disease

Methotrexate showed no clear difference in failure to enter remission or possible remission at 24‐36 weeks… compared with 6‐MP or azathioprine (low certainty).

3 findings from 1 review