Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 1 · 14.3%High 0 · 0%

Dropout · opiate‐dependent pregnant women

Methadone showed no clear difference in dropout rate compared with buprenorphine (moderate certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 0.66 [0.37, 1.2]
3 studies · 223 participants
Moderate

Use of Primary Substance · opiate‐dependent pregnant women

Methadone showed no clear difference in use of primary substance compared with buprenorphine (low certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 1.81 [0.7, 4.68]
2 studies · 151 participants
Low

Birthweight (g) · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 19 participants
Very low

APGAR scoreScale from: 0 to 10 · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 163 participants
Low

Number treated for NAS · opiate‐dependent pregnant women

Methadone showed no clear difference in number treated for NAS compared with buprenorphine (low certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 1.19 [0.87, 1.63]
3 studies · 166 participants
Low

Proportion of mothers with serious adverse events ( · opiate‐dependent pregnant women

Methadone showed no clear difference in serious adverse events for the mother compared with buprenorphine (low certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 1.69 [0.75, 3.83]
1 study · 175 participants
Low

Serious adverse events for the child · opiate‐dependent pregnant women

Methadone showed no clear difference in serious adverse events for the child compared with buprenorphine (low certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 4.77 [0.59, 38.49]
1 study · 131 participants
Low