Findings

What do systematic reviews say?

24 questions · 24 findings · 4 reviews

No studies found 2 · 8.3%GRADE not reported 0 · 0%Very low 8 · 33.3%Low 11 · 45.8%Moderate 1 · 4.2%High 2 · 8.3%

Unacceptability of treatment (dropouts/exclusions during the trial) · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Use of substance · opiate‐dependent pregnant women

Methadone showed no clear difference in use of substance compared with oral slow‐release morphine (low certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 2.4 [1, 5.77]
1 study · 48 participants
Low

Completion of treatment Objective · patients with the management of opioid withdrawal

Tapered methadone showed no clear difference in completion of treatment Objective compared with any other treatment (high certainty).

1 finding from 1 review

Methadone at tapered doses for the management of opioid withdrawal 2013 · Cochrane Headline outcomes only
RR 1.08 [0.97, 1.21]
16 studies · 1381 participants
High

Abstinents at · patients with the management of opioid withdrawal

Tapered methadone showed no clear difference in number of participants abstinent at compared with any other treatment (high certainty).

1 finding from 1 review

Methadone at tapered doses for the management of opioid withdrawal 2013 · Cochrane Headline outcomes only
RR 0.98 [0.7, 1.37]
3 studies · 386 participants
High