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What do systematic reviews say?

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Evidence found and GRADE certainty

72 questions · 87 findings · 3 reviews · Metabolic and Endocrine Disorders

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No studies found 34 · 39.1%GRADE not reported 2 · 2.3%Very low 39 · 44.8%Low 10 · 11.5%Moderate 2 · 2.3%High 0 · 0%

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + GLP1‐A
2 findings from 1 review

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + DPP4‐I

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + DPP4‐I compared with metformin plus another antidiabetic drug (very low certainty).

3 findings from 1 review

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + thiazolidinedione

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + thiazolidinedione compared with metformin plus another antidiabetic drug (very low certainty).

2 findings from 1 review

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + nateglinide
4 findings from 1 review
Show 1 more finding

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + SGLT2‐I

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + SGLT2‐I compared with metformin plus another antidiabetic drug (very low certainty).

2 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Thiazolidinediones Diagnostic criteria: 2 trials applied the WHO 1999 criteria (FPG ≥ 7.0 mmol/L and/or a 2‐hour glucose ≥ 11.1 mmol/L after a 75 g OGTT) (Jin 2009; Zeng 2013). No medical association recommended the cut‐off points applied in Maji ... · people at increased risk for developing type 2 diabetes

Summary of findings table for metformin showed no clear difference in thiazolidinediones Diagnostic criteria: 2 trials applied the WHO… compared with diet and exercise or another antidiabetic drug (low certainty).

1 finding from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Intensive diet plus exercise · people at increased risk for developing type 2 diabetes
4 findings from 1 review
Show 1 more finding

Metformin vs diet and exercise or another antidiabetic drug

Acarbose · people at increased risk for developing type 2 diabetes
3 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Thiazolidinediones · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Placebo or diet and exercise · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Placebo or diet and exercise Description: SF‐36 to evaluate the health utility index SF‐6D (physical component summaries and mental component summaries) Minimal important difference: difference in scores between groups of at least 3% · people at increased risk for developing type 2 diabetes
1 finding from 1 review