What do systematic reviews say?

2 questions · 2 findings · 1 reviews · asked by two or more reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Metformin vs clomiphene

Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman Participants with BMI < 30 kg/m2… compared with clomiphene citrate (very low certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.56 [1.05, 2.33]
5 studies · 490 participants
Very low

Metformin vs clomiphene

Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman Participants with BMI ≥ 30 kg/m2a compared with clomiphene citrate (very low certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.34 [0.21, 0.55]
2 studies · 500 participants
Very low