Findings

What do systematic reviews say?

9 questions · 9 findings · 3 reviews

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No studies found 4 · 44.4%GRADE not reported 0 · 0%Very low 5 · 55.6%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

All‐cause mortality

The review found no eligible studies for this question.

1 finding from 1 review

Metformin and second‐ or third‐generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin vs diet and exercise or another antidiabetic drug

All‐cause mortality · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin vs insulin

All‐cause mortality

The review found no eligible studies for this question.

1 finding from 1 review

Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin vs thiazolidinediones

All‐cause mortality

It is very uncertain whether summary of findings of metformin monotherapy for adults with type 2… changes all‐cause mortality compared with thiazolidinediones (very low certainty).

1 finding from 1 review

Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
RR 0.88 [0.55, 1.39]
5 studies · 4402 participants
Very low

Metformin vs dipeptidyl‐peptidase 4 inhibitors

All‐cause mortality

1 finding from 1 review

Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1977 participants
Very low

Metformin vs glucagon like peptide‐1 analogues

All‐cause mortality

1 finding from 1 review

Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 807 participants
Very low

Metformin vs meglitinides

All‐cause mortality

The review found no eligible studies for this question.

1 finding from 1 review

Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin vs sulphonylureas

All‐cause mortality

1 finding from 1 review

Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 3129 participants
Very low

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

All‐cause mortality · people at increased risk for developing type 2 diabetes

1 finding from 1 review

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 450 participants
Very low