Mefloquine showed no clear difference in clinical malaria episodes during pregnancy compared with sulfadoxine‐pyrimethamine (high certainty).
Mefloquine plus cotrimoxazole showed no clear difference in clinical malaria episodes during pregnancy compared with cotrimoxazole (high certainty).
Mefloquine led to higher depressed mood compared with doxycycline; GRADE not reported.
Mefloquine led to higher depressed mood compared with atovaquone‐proguanil; GRADE not reported.
Mefloquine leads to lower maternal peripheral parasitaemia at delivery compared with sulfadoxine‐pyrimethamine (high certainty).
Mefloquine showed no clear difference in placental malaria compared with sulfadoxine‐pyrimethamine (low certainty).
Mefloquine probably leads to lower maternal anaemia at delivery compared with sulfadoxine‐pyrimethamine (moderate certainty).
Mefloquine showed no clear difference in low birth weight compared with sulfadoxine‐pyrimethamine (high certainty).
Mefloquine showed no clear difference in stillbirths and abortions compared with sulfadoxine‐pyrimethamine (moderate certainty).
Mefloquine leads to higher AEs: vomiting compared with sulfadoxine‐pyrimethamine (high certainty).
Mefloquine probably leads to higher AEs: dizziness compared with sulfadoxine‐pyrimethamine (moderate certainty).
Mefloquine plus cotrimoxazole probably leads to lower maternal peripheral parasitaemia at delivery (PCR) compared with cotrimoxazole (moderate certainty).
Mefloquine plus cotrimoxazole probably leads to lower placental malaria (PCR) compared with cotrimoxazole (moderate certainty).
Mefloquine plus cotrimoxazole showed no clear difference in maternal anaemia at delivery compared with cotrimoxazole (moderate certainty).
Mefloquine plus cotrimoxazole showed no clear difference in low birth weight compared with cotrimoxazole (moderate certainty).
It is very uncertain whether mefloquine plus cotrimoxazole changes spontaneous abortions and stillbirths compared with cotrimoxazole (very low certainty).
Mefloquine plus cotrimoxazole leads to higher AEs: vomiting compared with cotrimoxazole (high certainty).
Mefloquine plus cotrimoxazole leads to higher AEs: dizziness compared with cotrimoxazole (high certainty).
Mefloquine showed no clear difference in vomiting compared with atovaquone‐proguanil; GRADE not reported.