Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

Lutein with or without zeaxanthin vs placebo

Progression to geographic atrophy · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to geographic atrophy compared with placebo (low certainty).

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
RR 0.92 [0.8, 1.05]
1 study · 6891 participants
Low

Lutein with or without zeaxanthin vs placebo

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo (low certainty).

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
RR 0.98 [0.91, 1.05]
1 study · 6656 participants
Low

Lutein with or without zeaxanthin vs placebo

Quality of life · people with AMD

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 308 participants
Moderate

Lutein with or without zeaxanthin vs placebo

Adverse effects · people with AMD

It is very uncertain whether lutein with or without zeaxanthin changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
OR 1.06
Studies not reported
Very low

Lutein with or without zeaxanthin vs placebo

Resource use and costs · people with AMD

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lutein with or without zeaxanthin vs placebo

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo (low certainty).

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
RR 0.94 [0.87, 1.01]
1 study · 6891 participants
Low

Lutein with or without zeaxanthin vs placebo

Progression to neovascular AMD · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to neovascular AMD compared with placebo (low certainty).

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
RR 0.92 [0.84, 1.02]
1 study · 6891 participants
Low