Low-power CO2 laser irradiation (LLLT, 0.5 to 2 W) vs Placebo (placebo laser or placebo agent) or no treatment
White spot lesion incidence · High caries-risk patients: fixed-orthodontic-appliance patients and children with partially erupted permanent molars
Low-power CO2 laser (LLLT) is associated with a lower incidence of new white spot lesions than placebo (OR 0.21, CI 0.15 to 0.30; ungraded, 3 RCTs, considerable heterogeneity I2=71%).
1 finding from 1 review
- Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. 2024 All outcomes3 to 18 months follow-up · Clinical (in vivo); high caries-risk / orthodontic patientsOR 0.21 [0.15, 0.30]3 studies · 182 participantsGRADE not reported