What do systematic reviews say?

Low dose calcineurin inhibitors (CNI) vs standard dose CNI

• Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 2623 participants
  Moderate

Low dose calcineurin inhibitors (CNI) vs standard dose CNI

Low dose calcineurin inhibitors (CNI) showed no clear difference in graft loss compared with to standard dose CNI (moderate certainty).

• Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.75 [0.55, 1.02]
  15 studies · 3286 participants
  Moderate

Low dose calcineurin inhibitors (CNI) vs standard dose CNI

Low dose calcineurin inhibitors (CNI) showed no clear difference in adverse events: hypertension compared with to standard dose CNI (low certainty).

• Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.84 [0.7, 1]
  5 studies · 1877 participants
  Low

Low dose calcineurin inhibitors (CNI) vs standard dose CNI

Low dose calcineurin inhibitors (CNI) showed no clear difference in adverse events: CMV infection compared with to standard dose CNI (moderate certainty).

• Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 1.23 [0.94, 1.62]
  6 studies · 1948 participants
  Moderate

Low dose calcineurin inhibitors (CNI) vs standard dose CNI

Low dose calcineurin inhibitors (CNI) showed no clear difference in adverse events: malignancy compared with to standard dose CNI (low certainty).

• Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.9 [0.41, 1.97]
  5 studies · 1637 participants
  Low

Low dose calcineurin inhibitors (CNI) vs standard dose CNI

Low dose calcineurin inhibitors (CNI) showed no clear difference in death compared with to standard dose CNI (moderate certainty).

• Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.79 [0.5, 1.27]
  15 studies · 3462 participants
  Moderate

Low dose calcineurin inhibitors (CNI) vs standard dose CNI

Low dose calcineurin inhibitors (CNI) showed no clear difference in acute rejection compared with to standard dose CNI (moderate certainty).

• Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.87 [0.76, 1]
  19 studies · 3757 participants
  Moderate