Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 75%Low 0 · 0%Moderate 1 · 25%High 0 · 0%

Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

Long‐term red cell transfusion probably leads to lower clinical stroke compared with no transfusion (moderate certainty).

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.12 [0.03, 0.49]
2 studies · 326 participants
Moderate

Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 121 participants
Very low

Stroke · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes clinical stroke compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 14.78 [0.86, 253.66]
1 study · 133 participants
Very low

Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes clinical stroke compared with no transfusion (very low certainty).

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.22 [0.01, 4.35]
1 study · 79 participants
Very low