Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

SCD ‐ related SAEs ‐ ACS · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions

Long‐term RBC transfusions may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.24 [0.12, 0.49]
2 studies · 326 participants
Low

SCD‐related SAEs ‐ pain crisis · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions

Long‐term RBC transfusions may leads to lower SCD‐related SAEs ‐ pain crisis compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.63 [0.42, 0.95]
2 studies · 326 participants
Low

Stroke · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions

Long‐term RBC transfusions probably leads to lower clinical stroke compared with standard care (moderate certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.12 [0.03, 0.49]
2 studies · 326 participants
Moderate