Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Common Mental Disorders

No studies found 1 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 40%Moderate 2 · 40%High 0 · 0%

Efficacy: response (categorical) BMRS change ≥ 50% from baseline to end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Efficacy: response (continuous) YMRS/MRS change at the end of the study · acute mania

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 241 participants
Low

Efficacy: remission (categorical) YMRS ≤ 12/absence of DSM‐IV mania by end of study · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) YMRS ≤ 12/absence of DSM‐IV mania… compared with risperidone (low certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 1.3 [0.11, 14.95]
2 studies · 211 participants
Low

Acceptability: total withdrawals · acute mania

Lithium probably leads to higher acceptability: total withdrawals compared with risperidone (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 1.85 [1.02, 3.34]
3 studies · 255 participants
Moderate

Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · acute mania

Lithium probably leads to lower adverse events: drowsiness/ somnolence compared with risperidone (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.43 [0.24, 0.75]
2 studies · 219 participants
Moderate