Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Common Mental Disorders

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 2 · 40%Low 2 · 40%Moderate 0 · 0%High 0 · 0%

Lithium vs QUETIAPINE

Efficacy: response (categorical) YMRS change ≥ 50% from baseline to end of study · acute mania

It is very uncertain whether lithium changes efficacy: response (categorical) YMRS decrease by ≥ 50% by end of… compared with quetiapine (very low certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.66 [0.28, 1.55]
2 studies · 335 participants
Very low

Lithium vs QUETIAPINE

Efficacy: response (continuous) Change in YMRS (ITT‐LOCF) from baseline to end of study · acute mania

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 359 participants
Low

Lithium vs QUETIAPINE

Remission · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) Decrease in YMRS ≤ 12 by end of… compared with quetiapine (low certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.64 [0.26, 1.57]
2 studies · 359 participants
Low

Lithium vs QUETIAPINE

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with quetiapine (very low certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 1.38 [0.83, 2.28]
2 studies · 359 participants
Very low

Lithium vs QUETIAPINE

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found