Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Common Mental Disorders

No studies found 1 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 60%Moderate 1 · 20%High 0 · 0%

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

Lithium probably leads to lower efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score… compared with olanzapine (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.44 [0.2, 0.94]
2 studies · 180 participants
Moderate

Efficacy: response (continuous) CGI severity score at end of study · acute mania

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 210 participants
Low

Remission · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) YMRS ≤ 12 at end of study compared with olanzapine (low certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 2 [0.89, 4.46]
1 study · 140 participants
Low

Acceptability: total withdrawals · acute mania

Lithium may leads to higher acceptability: total withdrawals compared with olanzapine (low certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 2.6 [1.13, 5.99]
3 studies · 210 participants
Low

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found