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Evidence found and GRADE certainty

16 questions · 16 findings · 1 reviews

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No studies found 2 · 12.5%GRADE not reported 0 · 0%Very low 4 · 25%Low 5 · 31.3%Moderate 4 · 25%High 1 · 6.3%

Lithium vs lamotrigine

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 301 participants
    Moderate

Lithium vs placebo

Efficacy: response (continuous) Change in YMRS (ITT‐LOCF) from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    4 studies · 935 participants
    High

Lithium vs carbamazepine

Efficacy: response (continuous) YMRS/BPRS change from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 102 participants
    Very low

Lithium vs carbamazepine

Efficacy: response (continuous) CGI change from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 76 participants
    Moderate

Lithium vs QUETIAPINE

Efficacy: response (continuous) Change in YMRS (ITT‐LOCF) from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 359 participants
    Low

Lithium vs OLANZAPINE

Efficacy: response (continuous) CGI severity score at end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 210 participants
    Low

Lithium vs chlorpromazine

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 284 participants
    Very low

Lithium vs haloperidol

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 80 participants
    Very low

Lithium vs Zuclopenthixol (Cis Z/Trans E isomer)

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs RISPERIDONE

Efficacy: response (continuous) YMRS/MRS change at the end of the study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 241 participants
    Low

Lithium vs ARIPIPRAZOLE

Efficacy: response (continuous) YMRS change by ≥ 50% at end of study · acute mania

Lithium showed no clear difference in efficacy: response (continuous) YMRS change by ≥ 50% at end of study compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.96 [0.62, 1.51]
    1 study · 309 participants
    Moderate

Lithium vs topiramate

Efficacy: response (continuous) YMRS change by ≥ 50% at end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs clonazepam

Efficacy: response (continuous) CGI change from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 41 participants
    Moderate

Lithium vs ECT

Efficacy: response (continuous) MRS mean change from baseline to end of study · acute mania
1 finding from 1 review

Lithium vs valproate

Efficacy: response (continuous) Change in YMRS (ITT‐LOCF) from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    5 studies · 398 participants
    Very low