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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 5 · 71.4%High 0 · 0%

Lithium vs ARIPIPRAZOLE

Efficacy: response (categorical) BMRS change ≥ 50% from baseline to end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs ARIPIPRAZOLE

Efficacy: response (continuous) YMRS change by ≥ 50% at end of study · acute mania

Lithium showed no clear difference in efficacy: response (continuous) YMRS change by ≥ 50% at end of study compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.96 [0.62, 1.51]
    1 study · 309 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Remission · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) YMRS ≤ 12 at end of study compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.99 [0.63, 1.56]
    1 study · 309 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.94 [0.6, 1.46]
    1 study · 315 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Adverse event: tremor · acute mania

Lithium showed no clear difference in adverse events: tremor compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.45 [0.65, 3.24]
    1 study · 313 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Adverse events: somnolence/sedation · acute mania

Lithium showed no clear difference in adverse events: somnolence/sedation compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.56 [0.26, 1.23]
    1 study · 313 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Adverse events: clinically relevant (> 7%) weight gain · acute mania

Lithium showed no clear difference in adverse events: clinically relevant (> 7%) weight gain compared with aripiprazole (low certainty).

1 finding from 1 review