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Evidence found and GRADE certainty

30 questions · 30 findings · 1 reviews

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No studies found 16 · 53.3%GRADE not reported 0 · 0%Very low 2 · 6.7%Low 3 · 10%Moderate 4 · 13.3%High 5 · 16.7%

Lithium vs ARIPIPRAZOLE

Remission · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) YMRS ≤ 12 at end of study compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.99 [0.63, 1.56]
    1 study · 309 participants
    Moderate

Lithium vs topiramate

Efficacy: response (categorical) YMRS change ≥ 50% from baseline to end of study · acute mania

Lithium leads to higher efficacy: response (categorical) YMRS change ≥ 50% from baseline to… compared with topiramate (high certainty).

1 finding from 1 review

Lithium vs topiramate

Remission · acute mania

Lithium leads to higher efficacy: remission (categorical) YMRS ≤ 12 at end of study compared with topiramate (high certainty).

1 finding from 1 review

Lithium vs clonazepam

Efficacy: response (categorical) YMRS change ≥ 50% from baseline to end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs clonazepam

Efficacy : remission (categorical) YMRS ≤ 12 at end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs ECT

Efficacy: response (categorical) YMRS change ≥ 50% from baseline to end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs ECT

Remission · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs all antimanic agents

Efficacy: response (categorical) YMRS/MRS/BPRS change by ≥ 50% at end of study · acute mania

Lithium leads to higher efficacy: response (categorical) YMRS/MRS/BPRS change by ≥ 50% at… compared with all antimanic agents (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.36 [1.01, 1.83]
    14 studies · 3666 participants
    High

Lithium vs valproate

Efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end of study · acute mania

Lithium showed no clear difference in efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end… compared with valproate (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.22 [0.87, 1.7]
    5 studies · 607 participants
    Moderate