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Evidence found and GRADE certainty

8 questions · 8 findings · 1 reviews

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No studies found 4 · 50%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 0 · 0%Moderate 2 · 25%High 1 · 12.5%

Lithium vs QUETIAPINE

Efficacy: response (categorical) YMRS change ≥ 50% from baseline to end of study · acute mania

It is very uncertain whether lithium changes efficacy: response (categorical) YMRS decrease by ≥ 50% by end of… compared with quetiapine (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.66 [0.28, 1.55]
    2 studies · 335 participants
    Very low

Lithium vs placebo

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

Lithium leads to higher efficacy: response (categorical) YMRS/MRS decrease by ≥ 50% at end… compared with placebo (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 2.13 [1.73, 2.63]
    6 studies · 1707 participants
    High

Lithium vs lamotrigine

Efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs carbamazepine

Efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs valproate

Efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end of study · acute mania

Lithium showed no clear difference in efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end… compared with valproate (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.22 [0.87, 1.7]
    5 studies · 607 participants
    Moderate

Lithium vs OLANZAPINE

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

Lithium probably leads to lower efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score… compared with olanzapine (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.44 [0.2, 0.94]
    2 studies · 180 participants
    Moderate

Lithium vs chlorpromazine

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs haloperidol

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found