Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 60%High 2 · 40%

Somnolence · acute mania

Lithium leads to lower adverse event: somnolence compared with valproate (high certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.47 [0.29, 0.76]
4 studies · 575 participants
High

Somnolence · acute mania

Lithium showed no clear difference in adverse event: somnolence compared with lamotrigine (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 1.14 [0.34, 3.85]
2 studies · 272 participants
Moderate

Somnolence · acute mania

Lithium leads to higher adverse event: somnolence compared with placebo (high certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 2.28 [1.46, 3.58]
7 studies · 1351 participants
High

Adverse events: somnolence/sedation · acute mania

Lithium showed no clear difference in adverse events: somnolence/sedation compared with aripiprazole (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.56 [0.26, 1.23]
1 study · 313 participants
Moderate

Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · acute mania

Lithium probably leads to lower adverse events: drowsiness/ somnolence compared with risperidone (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.43 [0.24, 0.75]
2 studies · 219 participants
Moderate