Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 1 reviews

No studies found 2 · 13.3%GRADE not reported 0 · 0%Very low 4 · 26.7%Low 3 · 20%Moderate 3 · 20%High 3 · 20%

Lithium vs valproate

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with valproate (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.2 [0.86, 1.69]
    5 studies · 629 participants
    High

Lithium vs lamotrigine

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with lamotrigine (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.8 [0.5, 1.29]
    3 studies · 303 participants
    Very low

Lithium vs carbamazepine

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with carbamazepine (low certainty).

1 finding from 1 review

Lithium vs QUETIAPINE

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with quetiapine (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.38 [0.83, 2.28]
    2 studies · 359 participants
    Very low

Lithium vs OLANZAPINE

Acceptability: total withdrawals · acute mania

Lithium may leads to higher acceptability: total withdrawals compared with olanzapine (low certainty).

1 finding from 1 review

Lithium vs placebo

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with placebo (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.76 [0.46, 1.25]
    7 studies · 1353 participants
    Moderate

Lithium vs chlorpromazine

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with chlorpromazine (low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.75 [0.92, 3.31]
    2 studies · 262 participants
    Low

Lithium vs haloperidol

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with haloperidol (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.29 [0.03, 3.12]
    1 study · 30 participants
    Very low

Lithium vs Zuclopenthixol (Cis Z/Trans E isomer)

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with zuclopenthixol (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.78 [0.17, 3.49]
    1 study · 28 participants
    Very low

Lithium vs RISPERIDONE

Acceptability: total withdrawals · acute mania

Lithium probably leads to higher acceptability: total withdrawals compared with risperidone (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.85 [1.02, 3.34]
    3 studies · 255 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.94 [0.6, 1.46]
    1 study · 315 participants
    Moderate

Lithium vs topiramate

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with topiramate (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.28 [0.66, 2.48]
    2 studies · 1352 participants
    High

Lithium vs clonazepam

Acceptability: total withdrawals · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs ECT

Acceptability: total withdrawals · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs all antimanic agents

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with all antimanic agents (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.16 [0.89, 1.52]
    24 studies · 4201 participants
    High