What do systematic reviews say?

Levonorgestrel vs Yuzpe

Levonorgestrel leads to lower observed number of pregnancies (all women) compared with yuzpe (high certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 0.57 [0.39, 0.84]
  6 studies · 4750 participants
  High

Levonorgestrel vs Yuzpe

Levonorgestrel leads to lower any side effect compared with yuzpe (high certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 0.8 [0.75, 0.86]
  1 study · 1955 participants
  High

Levonorgestrel vs Yuzpe

Levonorgestrel probably leads to lower specific side effects ‐ Nausea compared with yuzpe (moderate certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 0.4 [0.36, 0.44]
  6 studies · 4750 participants
  Moderate

Levonorgestrel vs Yuzpe

Levonorgestrel probably leads to lower specific side effects ‐ Vomiting compared with yuzpe (moderate certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 0.29 [0.24, 0.35]
  5 studies · 3640 participants
  Moderate

Levonorgestrel vs Yuzpe

Levonorgestrel probably leads to higher specific side effects ‐ Spotting/bleeding after treatment compared with yuzpe (moderate certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 1.82 [1.37, 2.41]
  2 studies · 1614 participants
  Moderate

Levonorgestrel vs Yuzpe

Levonorgestrel showed no clear difference in menses ‐ Early compared with yuzpe (low certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 1.15 [0.86, 1.52]
  2 studies · 1310 participants
  Low

Levonorgestrel vs Yuzpe

Levonorgestrel showed no clear difference in menses ‐ Delay compared with yuzpe (low certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 1.23 [0.96, 1.57]
  3 studies · 1988 participants
  Low

Single‐dose levonorgestrel vs split‐dose levonorgestrel

Single‐dose levonorgestrel showed no clear difference in observed number of pregnancies (all women) compared with split‐dose levonorgestrel (moderate certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 0.84 [0.53, 1.33]
  3 studies · 6653 participants
  Moderate

Single‐dose levonorgestrel vs split‐dose levonorgestrel

The review found no eligible studies for this question.

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Single‐dose levonorgestrel vs split‐dose levonorgestrel

Single‐dose levonorgestrel showed no clear difference in specific side effects ‐ nausea compared with split‐dose levonorgestrel (moderate certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 0.97 [0.88, 1.07]
  3 studies · 6804 participants
  Moderate

Single‐dose levonorgestrel vs split‐dose levonorgestrel

Single‐dose levonorgestrel showed no clear difference in specific side effects ‐ vomiting compared with split‐dose levonorgestrel (moderate certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 1.01 [0.83, 1.22]
  3 studies · 6804 participants
  Moderate

Single‐dose levonorgestrel vs split‐dose levonorgestrel

Single‐dose levonorgestrel showed no clear difference in specific side effects ‐ spotting/bleeding after treatment compared with split‐dose levonorgestrel (moderate certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 1 [0.9, 1.12]
  1 study · 2720 participants
  Moderate

Single‐dose levonorgestrel vs split‐dose levonorgestrel

Single‐dose levonorgestrel leads to lower menses ‐ early compared with split‐dose levonorgestrel (high certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 0.67 [0.54, 0.82]
  1 study · 1118 participants
  High

Single‐dose levonorgestrel vs split‐dose levonorgestrel

Single‐dose levonorgestrel showed no clear difference in menses ‐ delay compared with split‐dose levonorgestrel (low certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 1.18 [0.96, 1.46]
  2 studies · 3784 participants
  Low

Summary of findings table ‐ Levonorgestrel IUDs vs Copper IUDs

• Progestin intrauterine devices versus copper intrauterine devices for emergency contraception 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 638 participants
  Very low

Summary of findings table ‐ Levonorgestrel IUDs vs Copper IUDs

It is very uncertain whether summary of findings table ‐ Levonorgestrel IUDs changes failed insertion compared with copper IUDs (very low certainty).

• Progestin intrauterine devices versus copper intrauterine devices for emergency contraception 2023 · Cochrane Headline outcomes only
  RR 1.05 [0.58, 1.9]
  1 study · 711 participants
  Very low

Summary of findings table ‐ Levonorgestrel IUDs vs Copper IUDs

It is very uncertain whether summary of findings table ‐ Levonorgestrel IUDs changes rates of expulsion compared with copper IUDs (very low certainty).

• Progestin intrauterine devices versus copper intrauterine devices for emergency contraception 2023 · Cochrane Headline outcomes only
  RR 0.67 [0.11, 4]
  1 study · 655 participants
  Very low

Summary of findings table ‐ Levonorgestrel IUDs vs Copper IUDs

It is very uncertain whether summary of findings table ‐ Levonorgestrel IUDs changes rates of removal compared with copper IUDs (very low certainty).

• Progestin intrauterine devices versus copper intrauterine devices for emergency contraception 2023 · Cochrane Headline outcomes only
  RR 1.25 [0.5, 3.14]
  1 study · 655 participants
  Very low

Summary of findings table ‐ Levonorgestrel IUDs vs Copper IUDs

• Progestin intrauterine devices versus copper intrauterine devices for emergency contraception 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 510 participants
  Low

Summary of findings table ‐ Levonorgestrel IUDs vs Copper IUDs

• Progestin intrauterine devices versus copper intrauterine devices for emergency contraception 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 547 participants
  Low