Findings

What do systematic reviews say?

164 questions · 176 findings · 17 reviews

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No studies found 48 · 27.3%GRADE not reported 21 · 11.9%Very low 87 · 49.4%Low 16 · 9.1%Moderate 4 · 2.3%High 0 · 0%

Anti‐vascular endothelial growth factor therapy combined with laser/cryotherapy vs conventional laser/cryotherapy

Structural outcome ‐ retinal detachment · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy combined with… may leads to lower structural outcome ‐ retinal detachment (unit of analysis: eyes) compared with laser/cryotherapy (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity 2018 · Cochrane Headline outcomes only
RR 0.26 [0.12, 0.55]
1 study · 152 participants
Low

Anti‐vascular endothelial growth factor therapy combined with laser/cryotherapy vs conventional laser/cryotherapy

Local adverse effects ‐ perioperative retinal haemorrhages (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy combined with… changes local adverse effects ‐ perioperative retinal haemorrhages (unit of… compared with laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity 2018 · Cochrane Headline outcomes only
RR 0.62 [0.24, 1.56]
1 study · 152 participants
Very low

Anti‐vascular endothelial growth factor therapy combined with laser/cryotherapy vs conventional laser/cryotherapy

Recurrence of ROP by 55 weeks' PMA · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy combined with… may leads to lower recurrence of ROP by 55 weeks' postmenstrual age compared with laser/cryotherapy (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity 2018 · Cochrane Headline outcomes only
RR 0.29 [0.12, 0.7]
1 study · 76 participants
Low

Surgical removal of the lesion (surgical excision, laser surgery, cryotherapy) vs Placebo or no treatment

Outcome not reported · People with a diagnosis of oral leukoplakia

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
'We did not identify any RCTs that compared surgical treatments with placebo or no treatment.' Three surgical RCTs were found (Chee 2013, Lopez-Jornet 2013, Schwarz 2005) but all excluded because they did not include a…
Studies not reported
No studies found