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Evidence found and GRADE certainty

13 questions · 13 findings · 1 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 4 · 30.8%Very low 2 · 15.4%Low 2 · 15.4%Moderate 5 · 38.5%High 0 · 0%

Lamotrigine vs placebo

Recurrence of any episodes at one year (Young Mania Rating Scale (YMRS) total score ≥15 for manic episode) · bipolar disorder

Lamotrigine may leads to lower recurrence of any episodes at one year (Young Mania Rating Scale… compared with placebo (low certainty).

1 finding from 1 review

Lamotrigine vs placebo

Recurrence of any episodes at one year (Montgomery‐Asberg Depression Rating Scale (MADRS) total score ≥15 for depressive episode; Hamilton Depression Rating Scale (HDRS) total score ≥14 for depressive episode) · bipolar disorder

Lamotrigine showed no clear difference in recurrence of any episodes at one year (Montgomery‐Asberg Depression… compared with placebo (low certainty).

1 finding from 1 review

Lamotrigine vs placebo

Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder

Lamotrigine probably leads to lower recurrence of any episodes at one year for clinical worsening with… compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder

Lamotrigine probably leads to lower withdrawal from treatment due to any reason, 6‐12 months after… compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Any reported adverse effects up to 12 weeks after starting treatment (short term) · bipolar disorder

It is very uncertain whether lamotrigine changes any reported adverse effects up to 12 weeks after starting treatment… compared with placebo (very low certainty).

1 finding from 1 review

Lamotrigine vs placebo

Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder

Lamotrigine showed no clear difference in any reported adverse effects 6‐12 months after initiating the… compared with placebo (moderate certainty).

1 finding from 1 review