Findings

What do systematic reviews say?

67 questions · 74 findings · 7 reviews

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No studies found 12 · 16.2%GRADE not reported 4 · 5.4%Very low 14 · 18.9%Low 34 · 45.9%Moderate 10 · 13.5%High 0 · 0%

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Liver T2* value · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 127 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

LIC · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 123 participants
Moderate

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Adverse events · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 234 participants
Very low

Sulodexide (heparin plus dermatan sulphate chains) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
Sulodexide was not associated with significant adverse events.
1 study · 20 participants
GRADE not reported

Sulodexide (heparin plus dermatan sulphate chains) vs placebo

Days to resolution of pain / epithelialization; number of aphthae per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
The trial by Femiano 2003 (high risk of bias) also compared sulodexide with placebo. Data were incompletely presented (ranges/totals only) precluding further analysis.
1 study · 20 participants
GRADE not reported

Sulodexide (heparin plus dermatan sulphate chains) vs prednisone

Overall effectiveness (days to resolution; number of aphthae per month) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
A comparison between sulodexide (n=10) and prednisone (n=10) was made in a trial at high risk of bias (Femiano 2003). Data presented as ranges/totals only with no estimate of variability, precluding further analysis.…
1 study · 20 participants
GRADE not reported

Sulodexide (heparin plus dermatan sulphate chains) vs prednisone

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
Sulodexide was without significant adverse events; one significant adverse event (gastritis) was reported for the prednisone group.
1 study · 20 participants
GRADE not reported