Findings

What do systematic reviews say?

13 questions · 13 findings · 1 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 23.1%Moderate 10 · 76.9%High 0 · 0%

LMWH prophylaxis vs UFH

All‐cause mortality · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in mortality compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.82 [0.63, 1.07]
8 studies · 4260 participants
Moderate

LMWH prophylaxis vs UFH

Postoperative transfusion Median · People with cancer with perioperative thromboprophylaxis

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 734 participants
Low

LMWH prophylaxis vs UFH

Intraoperative blood loss (mL) · People with cancer with perioperative thromboprophylaxis

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 761 participants
Moderate

LMWH prophylaxis vs UFH

Postoperative drain volume · People with cancer with perioperative thromboprophylaxis

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1459 participants
Moderate

LMWH prophylaxis vs UFH

Thrombocytopenia · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in thrombocytopenia compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 3.07 [0.32, 29.33]
2 studies · 683 participants
Moderate

LMWH prophylaxis vs UFH

Any PE · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in any PE compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.49 [0.17, 1.47]
14 studies · 5588 participants
Moderate

LMWH prophylaxis vs UFH

Symptomatic DVT · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in symptomatic DVT compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.67 [0.27, 1.69]
8 studies · 2250 participants
Moderate

LMWH prophylaxis vs UFH

Symptomatic DVT measured as asymptomatic DVT · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in symptomatic DVT measured as asymptomatic DVT compared with UFH prophylaxis (low certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.86 [0.71, 1.05]
12 studies · 4938 participants
Low

LMWH prophylaxis vs UFH

Major bleeding · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in major bleeding compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 1.01 [0.69, 1.48]
9 studies · 3473 participants
Moderate

LMWH prophylaxis vs UFH

Minor bleeding · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in minor bleeding compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 1.01 [0.76, 1.33]
2 studies · 1194 participants
Moderate

LMWH prophylaxis vs UFH

Wound hematoma · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis probably leads to lower wound hematoma compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.7 [0.54, 0.92]
6 studies · 2827 participants
Moderate

LMWH prophylaxis vs UFH

Adverse events (Re‐operation for bleeding (reoperation for major bleeding within 30 days (yes/no))) · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in reoperation for bleeding compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.93 [0.57, 1.5]
4 studies · 1246 participants
Moderate

LMWH prophylaxis vs UFH

Intraoperative transfusion · People with cancer with perioperative thromboprophylaxis

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 737 participants
Low