Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 2 reviews

No studies found 4 · 12.1%GRADE not reported 0 · 0%Very low 16 · 48.5%Low 3 · 9.1%Moderate 10 · 30.3%High 0 · 0%

Heparin prophylaxis vs no treatment/placebo

Symptomatic thromboembolic events ( · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic thromboembolic events ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Symptomatic PE · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic PE ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Symptomatic DVT · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic DVT ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Adverse effects sufficient to stop treatment · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes adverse effects sufficient to stop treatment compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic thromboembolic events (timing of assessment unclear,… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic PE · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic PE (timing of assessment unclear, within 6 weeks… compared with no treatment/placebo (very low certainty).

1 finding from 1 review