Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 1 · 16.7%Moderate 1 · 16.7%High 0 · 0%

Heparin prophylaxis vs no treatment/placebo

Symptomatic DVT · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic DVT ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
RR 0.33 [0.04, 3.1]
4 studies · 227 participants
Very low

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic DVT · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1140 participants
Very low

LMWH prophylaxis vs UFH

Symptomatic DVT · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in symptomatic DVT compared with UFH prophylaxis (moderate certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.67 [0.27, 1.69]
8 studies · 2250 participants
Moderate

LMWH prophylaxis vs UFH

Symptomatic DVT · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 287 participants
Very low

LMWH prophylaxis vs UFH

Symptomatic DVT measured as asymptomatic DVT · People with cancer with perioperative thromboprophylaxis

LMWH prophylaxis showed no clear difference in symptomatic DVT measured as asymptomatic DVT compared with UFH prophylaxis (low certainty).

1 finding from 1 review

Anticoagulation for perioperative thromboprophylaxis in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.86 [0.71, 1.05]
12 studies · 4938 participants
Low

Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH

Symptomatic DVT · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1 trial),…

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): LMWH changes symptomatic DVT (timing of assessment unclear, within 6 weeks… compared with UFH (very low certainty).

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.99]
3 studies · 217 participants
Very low