What do systematic reviews say?

Esketamine vs placebo

Esketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  OR 2.11 [1.2, 3.68]
  Studies not reported
  Low

Esketamine vs placebo

Esketamine probably leads to higher efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (moderate certainty).

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  OR 2.74 [1.71, 4.4]
  Studies not reported
  Moderate

Esketamine vs placebo

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Esketamine vs placebo

Esketamine showed no clear difference in acceptability: total dropouts№ of participants: 773(5 RCTs) compared with placebo (moderate certainty).

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  OR 1.58 [0.92, 2.73]
  Studies not reported
  Moderate

Esketamine vs placebo

The review found no eligible studies for this question.

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found