Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 1 · 25%Moderate 1 · 25%High 0 · 0%

Ketamine vs midazolam

Remission · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether ketamine changes efficacy: number of participants who achieve remission ‐ at 24 hours compared with midazolam (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 1.33 [0.07, 25.91]
1 study · 16 participants
Very low

Ketamine vs midazolam

Remission · adults with Major Depressive Disorder

Ketamine showed no clear difference in efficacy: number of participants who achieve remission ‐ at 24 hours compared with midazolam (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
OR 2.21 [0.67, 7.32]
Studies not reported
Low

Ketamine vs placebo

Remission · adults with Major Depressive Disorder

It is very uncertain whether ketamine changes efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
OR 5.6 [1.07, 29.46]
Studies not reported
Very low

Esketamine vs placebo

Remission · adults with Major Depressive Disorder

Esketamine probably leads to higher efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (moderate certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
OR 2.74 [1.71, 4.4]
Studies not reported
Moderate