Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Active TB · HIV‐positive children not taking ART

Isoniazid prophylaxis may leads to lower active TB compared with placebo (low certainty).

1 finding from 1 review

Isoniazid for preventing tuberculosis in HIV‐infected children 2017 · Cochrane Headline outcomes only
HR 0.31 [0.11, 0.87]
1 study · 240 participants
Low

Death · HIV‐positive children not taking ART

Isoniazid prophylaxis may leads to lower death compared with placebo (low certainty).

1 finding from 1 review

Isoniazid for preventing tuberculosis in HIV‐infected children 2017 · Cochrane Headline outcomes only
HR 0.46 [0.22, 0.95]
1 study · 240 participants
Low

Active TB · Children living with HIV receiving ART

It is very uncertain whether isoniazid prophylaxis changes active TB compared with placebo (very low certainty).

1 finding from 1 review

Isoniazid for preventing tuberculosis in HIV‐infected children 2017 · Cochrane Headline outcomes only
RR 0.76 [0.5, 1.14]
3 studies · 737 participants
Very low

Death · Children living with HIV receiving ART

It is very uncertain whether isoniazid prophylaxis changes death compared with placebo (very low certainty).

1 finding from 1 review

Isoniazid for preventing tuberculosis in HIV‐infected children 2017 · Cochrane Headline outcomes only
RR 1.45 [0.78, 2.72]
3 studies · 737 participants
Very low