Findings

What do systematic reviews say?

21 questions · 26 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 11.5%Low 7 · 26.9%Moderate 11 · 42.3%High 5 · 19.2%

Severe adverse effects · people with metastatic CRC

Irinotecan + targeted therapy leads to higher severe adverse effects compared with irinotecan (high certainty).

1 finding from 1 review

Second‐line systemic therapy for metastatic colorectal cancer 2017 · Cochrane Headline outcomes only
RR 1.44 [1.31, 1.59]
2 studies · 1704 participants
High