Findings

What do systematic reviews say?

28 questions · 28 findings · 3 reviews

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No studies found 8 · 28.6%GRADE not reported 1 · 3.6%Very low 4 · 14.3%Low 5 · 17.9%Moderate 9 · 32.1%High 1 · 3.6%

Intravenous midazolam vs intravenous diazepam

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous diazepam (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.5 [0.1, 2.58]
1 study · 80 participants
Moderate

Intravenous midazolam vs intravenous diazepam

Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous midazolam vs intravenous lorazepam

Seizure freedom · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure cessation compared with intravenous lorazepam (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.98 [0.91, 1.04]
1 study · 80 participants
Moderate

Intravenous midazolam vs intravenous lorazepam

Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Moderate

Intravenous midazolam vs intravenous lorazepam

Incidence of respiratory depression · Children with acute tonic‐clonic seizures

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
High

Intravenous midazolam vs intravenous lorazepam

Additional drugs required to stop the seizure: additional dose of the trial drug required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in additional drugs required to terminate the seizure: additional dose… compared with intravenous lorazepam (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 3 [0.13, 71.51]
1 study · 80 participants
Moderate

Intravenous midazolam vs intravenous lorazepam

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous lorazepam (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1 [0.15, 6.76]
1 study · 80 participants
Moderate

Intravenous midazolam vs intravenous lorazepam

Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found