What do systematic reviews say?

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

The review found no eligible studies for this question.

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intravenous acetylcysteine vs placebo

Intravenous acetylcysteine may leads to lower mortality compared with placebo (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.29 [0.09, 0.94]
  1 study · 50 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.67 [0.11, 4.08]
  1 study · 202 participants
  Very low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics from 0‐2 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.3 [0.17, 0.53]
  1 study · 217 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics 0‐12 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.4 [0.22, 0.75]
  1 study · 203 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower anaphylactoid symptoms compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.39 [0.21, 0.7]
  1 study · 208 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 222 participants
  Very low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 180 participants
  Very low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

It is very uncertain whether initial infusion rate of intravenous acetylcysteine over 15 minutes changes hepatotoxicity compared with 60 minutes (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 1.34 [0.39, 4.56]
  1 study · 175 participants
  Very low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

Initial infusion rate of intravenous acetylcysteine over 15 minutes may leads to lower any adverse event compared with 60 minutes (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.51 [0.27, 0.96]
  1 study · 180 participants
  Low