Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Vascular

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Intra‐arterial delivery vs intravenous delivery

30‐Day amputation‐free survival · patients with < 30 days' limb ischaemiaa

It is very uncertain whether intra‐arterial delivery changes 30‐Day amputation‐free survival compared with intravenous delivery (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 1.71 [0.4, 7.34]
1 study · 40 participants
Very low

Intra‐arterial delivery vs intravenous delivery

Amputation · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Low

Intra‐arterial delivery vs intravenous delivery

30‐Day mortality · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Low

Intra‐arterial delivery vs intravenous delivery

Vessel patency ‐ radiological success ‐ complete (to end of treatment) · patients with < 30 days' limb ischaemiaa

Intra‐arterial delivery may leads to higher vessel patency ‐ radiological success ‐ complete (to end of treatment) compared with intravenous delivery (low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 13.22 [2.79, 62.67]
1 study · 40 participants
Low

Intra‐arterial delivery vs intravenous delivery

Duration of thrombolysis (to end of treatment) · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Very low

Intra‐arterial delivery vs intravenous delivery

CVA (up to 6 months) · patients with < 30 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Very low

Intra‐arterial delivery vs intravenous delivery

Major bleeding · patients with < 30 days' limb ischaemiaa

It is very uncertain whether intra‐arterial delivery changes major bleeding (up to 6 months) compared with intravenous delivery (very low certainty).

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
OR 0.12 [0.01, 2.53]
1 study · 40 participants
Very low