What do systematic reviews say?

Interventions vs placebo or no prophylaxis

Interventions showed no clear difference in all‐cause mortality in ICU compared with placebo or no prophylaxis (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.1 [0.9, 1.34]
  19 studies · 2159 participants
  Low