Findings

What do systematic reviews say?

30 questions · 37 findings · 3 reviews

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No studies found 7 · 18.9%GRADE not reported 7 · 18.9%Very low 13 · 35.1%Low 10 · 27%Moderate 0 · 0%High 0 · 0%

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Menstrual blood loss PBAC score

2 findings from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Low
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Menstrual blood loss Number of pads (diary record)

2 findings from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Low
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 110 participants
Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Duration of bleeding Number of bleeding days

2 findings from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Low
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 290 participants
Very low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Adverse effects: headache

Interventions (vitamin B1, mefenamic acid, tranexamic acid) showed no clear difference in side effects: headache compared with placebo or active comparators (desmopressin, sodium diclofenac,… (low certainty).

1 finding from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
OR 0.58 [0.18, 1.92]
1 study · 100 participants
Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Vomiting

Interventions (vitamin B1, mefenamic acid, tranexamic acid) showed no clear difference in side effects: vomiting compared with placebo or active comparators (desmopressin, sodium diclofenac,… (low certainty).

1 finding from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
OR 0.74 [0.25, 2.18]
1 study · 100 participants
Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Vitamin B1 vs placebo

1 finding from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Duration of bleeding (menstrual diary)

2 findings from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 110 participants
Low
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Side effects or other adverse events

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Menstrual blood loss: mean loss

2 findings from 1 review

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 94 participants
Low
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Intravenous injection of tranexamic acid · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in intravenous injection of tranexamic acid compared with placebo or no treatment (low certainty).

1 finding from 1 review

Interventions to reduce haemorrhage during myomectomy for fibroids 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Low