Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Epilepsy

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 1 · 14.3%Moderate 1 · 14.3%High 0 · 0%

Intermittent phenobarbital vs placebo or no treatment

Recurrent seizure at 6 months · children with febrile seizures

It is very uncertain whether intermittent phenobarbital changes recurrent seizure at 6 months compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 1.37 [0.67, 2.81]
2 studies · 281 participants
Very low

Intermittent phenobarbital vs placebo or no treatment

Recurrent seizure at 12 months · children with febrile seizures

Intermittent phenobarbital showed no clear difference in recurrent seizure at 12 months compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 1.01 [0.65, 1.59]
2 studies · 281 participants
Moderate

Intermittent phenobarbital vs placebo or no treatment

Recurrent seizure at 18 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intermittent phenobarbital vs placebo or no treatment

Recurrent seizure at 24 months · children with febrile seizures

Intermittent phenobarbital showed no clear difference in recurrent seizure at 24 months compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.85 [0.57, 1.28]
1 study · 249 participants
Low

Intermittent phenobarbital vs placebo or no treatment

Recurrent seizure at 36 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intermittent phenobarbital vs placebo or no treatment

Recurrent seizure at 48 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intermittent phenobarbital vs placebo or no treatment

Recurrent seizure at 60 months or greater · children with febrile seizures

It is very uncertain whether intermittent phenobarbital changes recurrent seizure at 60 months or greater compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.83 [0.28, 2.44]
1 study · 60 participants
Very low