Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 0 · 0%Low 0 · 0%Moderate 2 · 66.7%High 0 · 0%

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
RR 1.96 [1, 3.84]
1 study · 44 participants
Moderate

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ pre‐ and postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
RR 11.76 [0.71, 195.11]
1 study · 38 participants
Moderate

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

1 finding from 1 review

Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
Studies not reported
GRADE not reported