What do systematic reviews say?

More intensive vs less intensive insulin therapy

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 301 participants
  Very low

More intensive vs less intensive insulin therapy

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Very low

More intensive vs less intensive counselling

More intensive leads to higher smoking cessation at longest compared with less intensive counselling (high certainty).

• Individual behavioural counselling for smoking cessation 2017 · Cochrane Headline outcomes only
  RR 1.29 [1.09, 1.53]
  11 studies · 2920 participants
  High

Intensive follow‐up vs less intensive follow‐up

Intensive follow‐up showed no clear difference in overall survival compared with less intensive follow‐up (high certainty).

• Follow‐up strategies for patients treated for non‐metastatic colorectal cancer 2019 · Cochrane Headline outcomes only
  HR 0.91 [0.8, 1.04]
  15 studies · 12528 participants
  High

Intensive follow‐up vs less intensive follow‐up

Intensive follow‐up showed no clear difference in colorectal cancer‐specific survival compared with less intensive follow‐up (moderate certainty).

• Follow‐up strategies for patients treated for non‐metastatic colorectal cancer 2019 · Cochrane Headline outcomes only
  HR 0.93 [0.81, 1.07]
  11 studies · 11771 participants
  Moderate

Intensive follow‐up vs less intensive follow‐up

Intensive follow‐up showed no clear difference in relapse‐free survival compared with less intensive follow‐up (high certainty).

• Follow‐up strategies for patients treated for non‐metastatic colorectal cancer 2019 · Cochrane Headline outcomes only
  HR 1.05 [0.92, 1.21]
  16 studies · 8047 participants
  High

Intensive follow‐up vs less intensive follow‐up

Intensive follow‐up leads to higher salvage surgery (surgery at relapse with curative intent) compared with less intensive follow‐up (high certainty).

• Follow‐up strategies for patients treated for non‐metastatic colorectal cancer 2019 · Cochrane Headline outcomes only
  RR 1.98 [1.53, 2.56]
  13 studies · 5157 participants
  High

Intensive follow‐up vs less intensive follow‐up

Intensive follow‐up probably leads to lower interval recurrences (recurrence CRC diagnosed between scheduled compared with less intensive follow‐up (moderate certainty).

• Follow‐up strategies for patients treated for non‐metastatic colorectal cancer 2019 · Cochrane Headline outcomes only
  RR 0.59 [0.41, 0.86]
  7 studies · 3933 participants
  Moderate

Intensive follow‐up vs less intensive follow‐up

It is very uncertain whether intensive follow‐up changes harms Colonoscopy complications ‐ bowel perforation compared with less intensive follow‐up (very low certainty).

• Follow‐up strategies for patients treated for non‐metastatic colorectal cancer 2019 · Cochrane Headline outcomes only
  RR 6.83 [0.36, 131.21]
  1 study · 326 participants
  Very low