What do systematic reviews say?

Insulin glargine vs NPH insulin

Insulin glargine showed no clear difference in all‐cause mortality compared with NPH insulin (low certainty).

• (Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
  Peto OR 1.06 [0.62, 1.82]
  14 studies · 6173 participants
  Low

Insulin glargine vs NPH insulin

• (Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  16 studies · 5809 participants
  Low