Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Metabolic and Endocrine Disorders

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 1 · 14.3%High 0 · 0%

Summary of findings: insulin detemir vs NPH insulin

Health‐related quality of life

1 finding from 1 review · compare the 2 reviews

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 873 participants
Very low

Summary of findings: insulin detemir vs NPH insulin

All‐cause mortality

Insulin detemir showed no clear difference in all‐cause mortality compared with NPH insulin (low certainty).

1 finding from 1 review · compare the 2 reviews

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
Peto OR 0.74 [0.2, 2.65]
8 studies · 2328 participants
Low

Summary of findings: insulin detemir vs NPH insulin

AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation

Insulin detemir showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
RR 0.88 [0.64, 1.2]
1 study · 8 participants
Moderate

Summary of findings: insulin detemir vs NPH insulin

Socioeconomic effects

The review found no eligible studies for this question.

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: insulin detemir vs NPH insulin

HbA1c (%)

1 finding from 1 review · compare the 2 reviews

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2233 participants
Low

Summary of findings: insulin detemir vs NPH insulin

Diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3) Progression in retinopathy (4) Amputations (5) ESRD

It is very uncertain whether insulin detemir changes diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3)… compared with NPH insulin (very low certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
RR 1.5 [0.68, 3.32]
1 study · 2 participants
Very low

Summary of findings: insulin detemir vs NPH insulin

Hypoglycaemic episodes

It is very uncertain whether insulin detemir changes hypoglycaemic episodes (1) Severe hypoglycaemia (2) Serious… compared with NPH insulin (very low certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
RR 0.45 [0.17, 1.2]
1 study · 5 participants
Very low