Findings

What do systematic reviews say?

32 questions · 35 findings · 4 reviews

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No studies found 4 · 11.4%GRADE not reported 6 · 17.1%Very low 6 · 17.1%Low 12 · 34.3%Moderate 6 · 17.1%High 1 · 2.9%

Summary of findings: insulin detemir vs insulin glargine

HbA1c (%)

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 763 participants
Low

Summary of findings: insulin detemir vs NPH insulin

Severe hypoglycaemia

Summary of findings: insulin detemir probably leads to lower severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with NPH insulin (moderate certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
RR 0.69 [0.52, 0.92]
8 studies · 3219 participants
Moderate

Summary of findings: insulin detemir vs NPH insulin

Non‐fatal myocardial infarction/stroke Definition: myocardial infarction

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 495 participants
Low

Summary of findings: insulin detemir vs NPH insulin

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)

Summary of findings: insulin detemir showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
RR 0.67 [0.39, 1.17]
7 studies · 2925 participants
Moderate

Summary of findings: insulin detemir vs NPH insulin

Serious adverse events (n/N)

Summary of findings: insulin detemir showed no clear difference in serious adverse events (n/N) compared with NPH insulin (moderate certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
RR 0.95 [0.75, 1.21]
9 studies · 3332 participants
Moderate

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Macrosomia · pregnant women with pre‐existing diabetes

1 finding from 1 review

Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Perinatal mortality · pregnant women with pre‐existing diabetes

1 finding from 1 review

Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Pre‐eclampsia · pregnant women with pre‐existing diabetes

1 finding from 1 review

Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Caesarean section · pregnant women with pre‐existing diabetes

1 finding from 1 review

Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Fetal anomaly (major) · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin Detemir + prandial insulin Aspart changes fetal anomaly (major) compared with NPH insulin + prandial insulin Aspart (Different insulin types… (very low certainty).

1 finding from 1 review

Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
RR 3.15 [0.33, 29.67]
1 study · 162 participants
Very low

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Birth trauma including shoulder dystocia, nerve palsy, or fracture · pregnant women with pre‐existing diabetes

1 finding from 1 review

Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Composite outcome measure of neonatal morbidity · pregnant women with pre‐existing diabetes

1 finding from 1 review

Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported