What do systematic reviews say?

Human insulin vs animal insulin (Different insulin types within similar insulin regimens)

It is very uncertain whether human insulin changes macrosomia compared with animal insulin (Different insulin types within similar insulin… (very low certainty).

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  RR 0.22 [0.01, 4.3]
  1 study · 42 participants
  Very low

Insulin Aspart (+ NPH) vs human insulin (+ NPH insulin)

The review found no eligible studies for this question.

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes macrosomia compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  RR 0.49 [0.09, 2.54]
  1 study · 93 participants
  Very low

Insulin injected with a Novolin pen vs insulin injected with a needle or syringe (Different insulin regimens with similar insulin types used within the regimen)

It is very uncertain whether insulin injected with a Novolin pen changes macrosomia compared with insulin injected with a needle or syringe (Different insulin… (very low certainty).

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  RR 0.21 [0.03, 1.76]
  1 study · 93 participants
  Very low

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

• Different insulin types and regimens for pregnant women with pre‐existing diabetes 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported