Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

249 questions · 258 findings · 25 reviews

No studies found 52 · 20.2%GRADE not reported 8 · 3.1%Very low 71 · 27.5%Low 56 · 21.7%Moderate 61 · 23.6%High 10 · 3.9%

Summary of findings ‐ Inhaled mannitol vs dornase alfa

Lung function: FEV1 mL (percentage change from baseline) · children and young adults with CF

It is very uncertain whether summary of findings ‐ Inhaled mannitol changes lung function: FEV1 mL (percentage change from baseline) compared with dornase alfa (very low certainty).

1 finding from 1 review

Summary of findings ‐ Inhaled mannitol vs dornase alfa

Lung function: FEF25‐75 mL/s (percentage change from baseline) · children and young adults with CF

It is very uncertain whether summary of findings ‐ Inhaled mannitol changes lung function: FEF25-75 mL/s (percentage change from baseline) compared with dornase alfa (very low certainty).

1 finding from 1 review