Findings

What do systematic reviews say?

86 questions · 87 findings · 5 reviews

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No studies found 36 · 41.4%GRADE not reported 5 · 5.7%Very low 27 · 31%Low 13 · 14.9%Moderate 6 · 6.9%High 0 · 0%

Hypertonic saline 7% vs hypertonic saline

FEV1 % predicted: relative change from baseline · children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Hypertonic saline 7% vs hypertonic saline

FEV1 · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

LCI · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

All‐cause mortality · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

Measures of sputum clearance · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

Pulmonary exacerbations · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

Adverse events · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs Normal saline

Adverse events · people with bronchiectasis

Hypertonic saline showed no clear difference in adverse events compared with isotonic saline; GRADE not reported.

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
OR 8.2 [0.4, 169.9]
1 study · 40 participants
GRADE not reported

Hypertonic saline vs Normal saline

All‐cause mortality · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 113 participants
GRADE not reported

Hypertonic saline vs Normal saline

Symptoms: cough, sputum volume and ease of expectoration, wheeze, dyspnoea · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 113 participants
GRADE not reported

Hypertonic saline vs Normal saline

FEV1 (L) · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Moderate

Hypertonic saline vs Normal saline

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Moderate

Hypertonic saline vs Normal saline

Frequency and duration of exacerbations · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 70 participants
GRADE not reported

Hypertonic saline vs Normal saline

Hospital admissions · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
GRADE not reported

Hypertonic saline 3% to 7% vs Normal saline

FEV1 % predicted: relative change from baseline · adults and children with cystic fibrosis (stable lung disease)

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 246 participants
Very low

Hypertonic saline 3% to 7% vs Normal saline

LCI · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 3% to 7% vs Normal saline

All‐cause mortality · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 142 participants
Low

Hypertonic saline 3% to 7% vs Normal saline

Measures of sputum clearance · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 3% to 7% vs Normal saline

Pulmonary exacerbations · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

Hypertonic saline 3% to 7% showed no clear difference in pulmonary exacerbations compared with isotonic saline (low certainty).

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
HR 0.86 [0.57, 1.3]
1 study · 132 participants
Low

Hypertonic saline 3% to 7% vs Normal saline

Adverse events · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 142 participants
Very low