Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who have not had a stroke (primary prevention)

It is very uncertain whether hydroxyurea changes SCD‐related SAEs ‐ pain crisis compared with RBC transfusions (very low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 5.08 [0.61, 42.23]
1 study · 121 participants
Very low

SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who had a stroke (secondary prevention)

Hydroxyurea may leads to higher SCD‐related SAEs ‐ pain crisis compared with RBC transfusion (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 3.15 [1.23, 8.11]
1 study · 133 participants
Low