What do systematic reviews say?

High initial concentration vs low initial concentration

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 443 participants
  Low

High initial concentration vs low initial concentration

High initial concentration showed no clear difference in cough compared with low initial concentration (low certainty).

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  OR 1.23 [0.53, 2.81]
  8 studies · 589 participants
  Low

High initial concentration vs low initial concentration

High initial concentration showed no clear difference in laryngospasm compared with low initial concentration (low certainty).

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  OR 1.59 [0.16, 15.92]
  7 studies · 588 participants
  Low

High initial concentration vs low initial concentration

High initial concentration showed no clear difference in breath holding compared with low initial concentration (low certainty).

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  OR 1.16 [0.47, 2.83]
  5 studies · 389 participants
  Low

High initial concentration vs low initial concentration

High initial concentration may leads to higher apneoa compared with low initial concentration (low certainty).

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  RR 3.14 [1.72, 5.7]
  2 studies · 160 participants
  Low

High initial concentration vs low initial concentration

High initial concentration showed no clear difference in patient movement compared with low initial concentration (low certainty).

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  RR 1.14 [0.69, 1.89]
  5 studies · 445 participants
  Low

High initial concentration vs low initial concentration

High initial concentration showed no clear difference in bradycardia compared with low initial concentration (low certainty).

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  OR 0.8 [0.22, 2.88]
  3 studies · 199 participants
  Low