What do systematic reviews say?

High initial concentration vs low initial concentration

High initial concentration showed no clear difference in bradycardia compared with low initial concentration (low certainty).

• High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia 2016 · Cochrane Headline outcomes only
  OR 0.8 [0.22, 2.88]
  3 studies · 199 participants
  Low