Kidney cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Kidney cancer: OR 1.01 (95% CI 0.65 to 1.58), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Body‐mass index (BMI) · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Body mass index: Z score -0.15 (95% CI -0.19 to -0.11), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Sporadic colorectal adenoma · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Sporadic colorectal adenoma: OR 0.82 (95% CI 0.69 to 0.97), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Type 2 diabetes (prevalent) · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Type 2 diabetes (prevalent): OR 0.45 (95% CI 0.25 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All cause mortality · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality: HR 0.72 (95% CI 0.66 to 0.78), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Rectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Rectal cancer: OR 0.50 (95% CI 0.29 to 0.88), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Successful discontinuation rate · participants with long‐term antidepressants for depressive disorders
1 finding from 1 review
Risk of relapse (as defined by study authors) (HR) · participants with long‐term antidepressants for depressive disorders
Discontinuation with high‐intensity psychological interventions showed no clear difference in risk of relapse (as defined by study authors) (HR) compared with continuation (low certainty).
1 finding from 1 review
Withdrawal symptoms · participants with long‐term antidepressants for depressive disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · participants with long‐term antidepressants for depressive disorders
1 finding from 1 review
Depressive symptoms · participants with long‐term antidepressants for depressive disorders
1 finding from 1 review
Anxiety · participants with long‐term antidepressants for depressive disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · participants with long‐term antidepressants for depressive disorders
1 finding from 1 review
Social and occupational functioning · participants with long‐term antidepressants for depressive disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Restoration survival · Permanent posterior teeth with single-surface cavities
Single-surface high-viscosity glass-ionomer ART restorations in permanent teeth had high 2-year survival (93%, 95% CI 89-95%); evidence ungraded.
6 findings from 1 review
Show 3 more findings
Restoration survival · Primary posterior teeth with single-surface cavities
Single-surface high-viscosity glass-ionomer ART restorations in primary teeth had high 2-year survival (93%, 95% CI 91-94%); evidence ungraded.
3 findings from 1 review
Overall survival (OS) · stage III and IV cutaneous melanoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · stage III and IV cutaneous melanoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall response rate (ORR), · stage III and IV cutaneous melanoma
It is very uncertain whether neoadjuvant immunotherapy (high dose interferon) plus chemotherapy changes overall response rate (ORR), measured after 8 weeks of treatment and… compared with neoadjuvant chemotherapy (very low certainty).
1 finding from 1 review
Time to recurrence ‐ not measured · stage III and IV cutaneous melanoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found